The second call had more than 400 participants! Given the positive response during the call and multiple groups sharing early GWAS analyses on Slack, we aim to launch a first meta-analysis later this week. The broader analysis plan being developed is available here and we would expect to make available the first meta-analysis summary statistics immediately. We discuss two approaches in regards to…
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Mission
The COVID-19 host genetics initiative brings together the human genetics community to generate, share and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity and outcomes. Such discoveries could help to generate hypotheses for drug repurposing, identify individuals at unusually high or low risk, and contribute to global knowledge of the biology of SARS-CoV-2 infection and disease.
Objectives
The COVID-19 host genetics initiative is a bottom-up collaborative effort that has three main aims:
Aim 1: Provide an environment to foster the sharing of resources to facilitate COVID-19 host genetics research (e.g. protocols, questionnaires).
Aim 2: Organize analytical activities across studies to identify genetic determinants of COVID-19 susceptibility and severity.
Aim 3: Provide a platform to share the results from meta-analytical activities to benefit the broader scientific community.
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News
There are more than 100 studies participating to the initiative and we have launched a now portal to allow exploring studies research questions and foster collaborations. Next week we will start distributing a pilot analysis plan.
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On Friday, 27th of March we had the first call for data contributors. We have > 180 participants and very useful discussion. We are working on establishing a "matchmaking" area, where different study can connect to each other according to their research questions. We are also working on defining a set of core phenotypes to bring forward to discussion and analysis. We have established a new…
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The new website is live with more information and a new updated map of the partners.
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The collaboration with ICDA will help to reach the broad human genetics community and to organize the effort.
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The Rivas lab is making available a github repository with several relevant human genetic resources: https://github.com/rivas-lab/covid19
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Thanks to everyone for reaching out. We will organize soon a call with those interested in providing data.
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University of Siena has received ethical approval for sample collection. For more informations visit the wesbite: https://sites.google.com/dbm.unisi.it/gen-covid
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