Genetic and non-genetic causes of severe COVID-19
February 19, 2021

Written by Nirmal Vadgama, PhD Edited by Kumar Veerapen, PhD and Jamal Nasir, PhD Note: This blog post is catered to the lay audience. The COVID-19 Host Genetics Initiative (HGI) represents a consortium of over 1000 scientists from over 54 countries working collaboratively to share data, ideas, recruit patients and disseminate our findings. For a primer on our study design or the results from the…

Distinguishing causality from correlation -- What factors drive SARS-CoV-2 infection and Covid-19 Severity?
February 05, 2021

Written by Annika Faucon and Shea Andrews, PhD Edited by Kumar Veerapen, PhD Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic virus that emerged in late 2019 and as of February 2021 has resulted in more than 2.4 million deaths (further reading: Dong, Ru, and Gardner, 2020). The threat SARS-CoV-2 presents is not uniform; certain pre-existing…

January 25, 2021 meeting
January 29, 2021

Webinar 8: January 25th, 2021 9:00am EST / 2:00pm GMT / 3:00pm CET Agenda: 1. Welcome & updates (25 min) Topics & speakers: a. Results from data freeze 5 meta-analysis (Andrea Ganna, FIMM) [Slides] b. HGI data browser (Matt Solomonson, Broad Institute) 2. COVID-19 HGI manuscript update (25 min) Topics & speakers: a. Manuscript overview & figures (Mari Niemi, FIMM) [Slides] b. Next steps for HGI…

November 19, 2020 meeting
November 24, 2020

Webinar 8: November 23rd, 2020 9:00am EST / 2:00pm GMT / 3:00pm CET Agenda: 1. Welcome & updates Speakers: Andrea Ganna (FIMM) [Slides], Matthew Solomonson (Broad) [Slides] Group discussion 2. COVID-19 HGI manuscript update Topics & speakers: a. Manuscript development process and status updates (Andrea Ganna, FIMM) b. Proposed consortium review process (Ben Neale, MGH & Broad) c. Initial proposed…

COVID-19 HGI Results for Data Freeze 4 (October 2020)
November 24, 2020

Written by Jamal Nasir, Brooke Wolford, and Kumar Veerapen on behalf of the COVID-19 HGI Edited by Emi Harry, Atanu Kumar Dutta, and Rachel Liao Note: The COVID-19 Host Genetics Initiative (HGI) represents a consortium of over 1000 scientists from over 54 countries working collaboratively to share data, ideas, recruit patients and disseminate our findings. For a primer on our study design or the…

Disentangling the Molecular Relationships Underlying COVID-19 Severity
October 28, 2020

Written by Gita Pathak, PhD Edited by Brooke Wolford, BS & Kumar Veerapen, PhD The emergence of SARS-CoV-2 has drastically impacted global health by resulting in millions of COVID-19 cases and deaths of more than 200,000 individuals. The wide-ranging symptoms observed in COVID-19 patients have led researchers to focus on the diversity of the human genome for clues that may explain the individual…

October 23, 2020 meeting
October 28, 2020

Webinar 7: October 23rd, 2020 9am EDT / 1:00pm GMT / 2:00pm BST Agenda: 1. Welcome & updates (20 min) Speakers: Andrea Ganna (FIMM), Juha Karjalainen (FIMM), Brooke Wolford (UMich) & Kumar Veerapen (Broad) & group discussion [Slides] 2. Sequencing & analysis efforts for COVID19 samples (25 min) Speakers: Jack Kosmicki (Regeneron) [Slides] Brent Richards (McGill) [Slides] & group discussion…

In-silico follow-up results for freeze V4
October 22, 2020

DISCLAIMER: In-silico analyses posted in this page are uploaded by partners of the COVID-19 HGI, but not peer reviewed or subjected to extensive quality control by the community. Please keep that in mind when using these results. ------------------------------------------------------------------------- Please find the results from V3 (June 2020) here Fine-mapping Summary: We conducted statistical…

October 2, 2020 meeting
October 02, 2020

Webinar 6: October 2nd, 2020 9:00am EDT / 1:00pm GMT / 2:00pm BST Agenda: 1. Welcome & updates Speakers: Andrea Ganna, Juha Karjalainen & Mark Daly (FIMM) [slides] 2. Community talks presenting new science Speakers: Silva Kasela (NYGC) [Slides] Jenny Huffman (Million Veterans Program) [Slides] Gita Pathek (Yale) [Slides] Jeanne Savage (VU University) [Slides] Kenny Baillie (UEdinburgh & GenOMICC…

COVID-19 HGI Results for Data Freeze 3 (July 2020)
September 25, 2020

Brooke Wolford and Kumar Veerapen, on behalf of the COVID-19 HGI The COVID-19 pandemic has affected the everyday lives of societies around the world. Scientists around the world are working hard to better understand the virus and disease. We represent one such group—the COVID-19 Host Genetics Initiative (HGI)—an international team of geneticists focused on identifying human genetic variation that…

August 27, 2020 meeting
August 28, 2020

Webinar 5: August 27th, 2020 10:00am EDT / 2pm GMT / 3pm BST Agenda: 1. Welcome & updates (15 min) Speaker: Andrea Ganna (FIMM) [Slides] Reading: Analysis plan v1.1 2. Dissemination of scientific results (15 min) Speaker: Mark Daly (FIMM) [Slides] Ben Neale (MGH/Broad) & group discussion [Slides] 3. Lightning talks presenting new science (30 min) Speakers: Genevieve Roberts (Ancestry) [Slides…

July 2, 2020 meeting
July 02, 2020

Webinar 4: July 2nd, 2020 9:00pm EDT / 1pm GMT / 2pm BST Agenda: 1. Welcome & updates Speaker: Andrea Ganna (FIMM) [Slides] 2. Terms of use discussion Speaker: Mark Daly (FIMM) & group discussion Reading: ToU Proposal 3. Community updates Speakers: Patrick Sulem (deCODE) [Slides] Daniel Wilson (BDI, Oxford) [Slides] 4. Lightning talks presenting in silico analyses Contributors and results are…

In-silico follow-up results
June 29, 2020

Here we post the results from the in-silico follow up analysis done of summary statistics from release 3. Heritability, genetic correlations and MAGMA Summary: We created a map of candidate genomic regions associated with COVID19 phenotypes and explored the functional implications of the candidate variants/genes based on known bioinformatics sources using the functional annotation platform FUMA…

May 29, 2020 meeting
June 02, 2020

Webinar 3: 5/29/2020 9:00pm EDT / 1pm GMT / 2pm BST Agenda: 1. Welcome & updates Speakers: Mark Daly & Andrea Ganna (FIMM) [Slides] 2. Phenotype definitions v2 Speaker: James Priest (Stanford) [Slides] Reading: Phenotypes v2 3. Analysis update Speaker: Ben Neale (Broad Institute) [Slides] 4. Lightning talks presenting early results Speakers: Nick Manusco (USC) [Slides] Lea Davis (VUMC) [Slides…

Second release of meta-analysis results
May 17, 2020

Updated results and summary statistic downloads are now available from the (still small but growing!) COVID-19 GWAS meta-analysis. Analyses this time include severity, susceptibility and COVID-19 associated symptoms. Results are downloadable at As a reminder, these results are based on phenotype definition V1 and analysis plan V1 Thanks to early contributing…

COVID-19 host genetics initiative reference paper
May 15, 2020

The paper describing the initiative has been published on the European Journal of Human Genetics and available open access:

May 7, 2020 meeting
May 07, 2020

Webinar 2: 5/07/2020 4:00pm EDT / 8pm GMT / 9pm BST Agenda: Welcome & updates Speakers: Mark Daly (FIMM) & Andrea Ganna (FIMM) [Slides] Study curation & QC Speakers: Karolina Chwiałkowska (Medical University of Bialystok) & Margherita Francescatto (University of Trieste) [Slides] Ongoing studies and early results Speakers: Kári Stefánsson (deCODE) Alessandra Renieri (University of Siena) [Slides…

First round of meta analysis results
April 30, 2020

We have released the first round of meta-analysis results here. We want to thank the participating studies: - UK Biobank (analyzed by Danny Wilson, Konrad Karczewski, Tomoko Nakanishi and Manuel Rivas) - Finngen (analyzed by Juha Karjalainen) - Genes and Health (analyzed by David Van Heel) - Lifelines (analyzed by Patrick Deelen) - BioMe biobank (analyzed by Arden Moscati) Although we don’t pose…

Second call, first round of analyses and data sharing
April 20, 2020

The second call had more than 400 participants! Given the positive response during the call and multiple groups sharing early GWAS analyses on Slack, we aim to launch a first meta-analysis later this week. The broader analysis plan being developed is available here and we would expect to make available the first meta-analysis summary statistics immediately. We discuss two approaches in regards to…

April 17, 2020 meeting
April 17, 2020

9:00am EDT / 1pm GMT / 2pm BST Agenda: Welcome & updates (10min) Speakers: Mark Daly (FIMM); Andrea Ganna (FIMM) Data storage & sharing discussion (5min present; 10min Q&A) Speakers: Thomas Keane (EMBL-EBI); Anthony Philippakis (Broad Institute) For reference Data Sharing FAQ Phenotypes discussion (5min present; 25min Q&A) Speakers: Lea Davis (Vanderbilt); Mark Daly (FIMM) For reference…

New partner portal and gearing up for analysis
April 09, 2020

There are more than 100 studies participating to the initiative and we have launched a now portal to allow exploring studies research questions and foster collaborations. Next week we will start distributing a pilot analysis plan.

First call and new registration form
March 30, 2020

On Friday, 27th of March we had the first call for data contributors. We have > 180 participants and very useful discussion. We are working on establishing a "matchmaking" area, where different study can connect to each other according to their research questions. We are also working on defining a set of core phenotypes to bring forward to discussion and analysis. We have established a new…

New website
March 25, 2020

The new website is live with more information and a new updated map of the partners.

Collaboration with the International Common Disease Alliance (ICDA)
March 19, 2020

The collaboration with ICDA will help to reach the broad human genetics community and to organize the effort.

COVID-19 resources from the Rivas Lab
March 18, 2020

The Rivas lab is making available a github repository with several relevant human genetic resources:

Large collective response
March 18, 2020

Thanks to everyone for reaching out. We will organize soon a call with those interested in providing data.

First IRB approval
March 16, 2020

University of Siena has received ethical approval for sample collection. For more informations visit the wesbite: